Coming from the east, Highway 90 makes for an interesting, scenic drive to Marfa. Plan your fuel stops wisely, as it's possible to go almost 200 miles between cities. Highway 90 takes in a couple of all-but-ghost towns along the way, as well as the Trans-Pecos crossing and some breathtaking scenery. Travelers in more of a hurry may prefer to take Interstate 10 to Highway 67 from the east or Highway 90 from the west straight into Marfa.
The nearest airport is in El Paso, 190 miles west.